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Psychology and mental health

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Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD?

Article Abstract:

Evidence supporting the use of deficits on neurocognitive measures of executive functions is reviewed. Such deficits are a correlate of attention-deficit/hyperactivity disorder (ADHD) and show preliminary evidence of heritability and association with relevant candidate genes.

Author: Willcutt, Erik G., Pennington, Bruce F., Faraone, Stephen V., Biederman, Joseph, Nigg, Joel T., Waldman, Irwin D., Doyle, Alysa E., Seidman, Larry J., Peart, Joanne
Publisher: Blackwell Publishers Ltd.
Publication Name: Journal of Child Psychology and Psychiatry
Subject: Psychology and mental health
ISSN: 0021-9630
Year: 2005
United States, Science & research, Phenotype, Phenotypes, Attention-deficit hyperactivity disorder, Molecular genetics

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Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypes

Article Abstract:

Three studies which had previously reported no associations between polymorphisms of the DRD4 and DAT genes and DSM-IV defined attention deficit hyperactivity disorder (ADHD) were reanalyzed using population-based and DSM-IV defined ADHD sub-types. No significant associations were found for either DRD4 or DAT polymorphisms using DSM-IV ADHD subtypes.

Author: Willcutt, Erik G., Pennington, Bruce F., Neuman, Rosalind J., Todd, Richard D., Faraone, Stephen V., Smith, Shelley D., Hongyan, Huang, Smalley, Susan L., Nelson, Stanley F.
Publisher: Blackwell Publishers Ltd.
Publication Name: Journal of Child Psychology and Psychiatry
Subject: Psychology and mental health
ISSN: 0021-9630
Year: 2005
Child psychology, Dopamine receptors

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Subjects list: Research, United States, Genetic aspects, Attention deficit hyperactivity disorder
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