Presynaptic mechanisms of neurotransmission

Article Abstract:

The correlation between the molecular biology of synaptic proteins and the electrophysiology of presynaptic mechanisms was established in a recent symposium. William Betz, one of the speakers, provided an overview of the conditions surrounding the release or blockage of neural transmitters. The different synaptic events, synaptic-associated proteins and their role in synapse formation, and protein-protein interactions were expounded on by other key speakers. 'Neuropharmacology' is an extensive compilation of the speakers' studies.

Neural transmission, Synaptic transmission, Synapses

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Probing the function of novel genes in the nervous system: is antisense the answer?

Article Abstract:

The feasibility of using antisense oligonucleotides for in vitro and in vivo probing of genes expressed in the nervous system was discussed at an international symposium held in Mar. 1995 at Oxford, UK. The meeting also showcased the use of antisense as a therapeutic agent for the treatment of AIDS. Overall, the participants concluded that using antisense probes requires careful attention to the concentration and length of the oligonucleotide, the administration period, and the size of the oligomer.

Methods, Molecular probes

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Antisense gene knockdown in the nervous system revisited: optimism for the future

Article Abstract:

An Oxford symposium was conducted in Mar, 1997 to discuss the theories and practical application of antisense oligonucleotides (ODN) for gene knockdown. The symposium was attended by several researchers who discussed the biochemical activity and physiological effects of ODNs. Furthermore, the researchers emphasized the need for developing novel techniques that will enhance the applicability of the ODN-based approach in genetic engineering.

Usage, Genetic aspects, Genetic engineering, Oxford, England, Oligodeoxynucleotides

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