Progressive dysarthria: structural and functional brain correlations

Article Abstract:

A 57-year-old man complained of a progressively worsening ability to articulate in 1986 which began two years earlier. Neuropsychological tests exhibited no abnormalities in his brain. A nonvolumetric magnetic resonance imaging (MRI) and a positron emission tomography (PET) scan with fluorodeoxyglucose (FDG) also gave normal results. However, as the man's dysarthria worsened between 1986 and 1991, a volumetric MRI and a PET scan with FDG were repeated, showing a left-sided perisylvian lesion and perisylvian hypometabolism localized to the area of tissue loss.

Usage, Diagnosis, Magnetic resonance imaging, PET imaging, Positron emission tomography, Articulation disorders

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Alzheimer's disease: from gene to pathology

Article Abstract:

Alzheimer's disease is characterized by the presence of diffuse and neuritic plaques composed principally of the beta-amyloid peptide. The overproduction of beta-amyloid protein is found to lead to the development of the disease. Recent experiments using a transgenic mouse revealed that the accumulation of beta-amyloid cells in the brain was correlated with apoptosis and eventual neuronal cell death. Results prove that therapeutic approaches to Alzheimer's disease are relevant.

Research, Alzheimer's disease, Nervous system, Nerve degeneration

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Linkage and association in complex genetic diseases

Article Abstract:

Complex genetic diseases such as schizophrenia and bipolar disorder are caused by several genes which can be detected through parametric or nonparametric linkage analyses or by association studies. Parametric type of linkage analysis is not entirely viable because disease-causing alleles are subject to too many variables. Association studies are recommended because a valid association may be detected in a sample wherein linkage is not detectable.

Psychological aspects, Analysis, Physiological aspects, Genetic disorders, Chromosome abnormalities, Linkage (Genetics)

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