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Axon retraction and degeneration in development and disease

Article Abstract:

The developmental phenomena of exuberant axonal projections and synaptic connections are discussed. Both small-scale and large-scale axon pruning are essential for the generation of adult connectivity, as a mechanism for neural plasticity, for removal of axonal connections damaged in the adult, for stabilization of the affected neural circuits and for initiating repairs.

Author: Liqun Luo, O'Leary, Dennis D.M.
Publisher: Annual Reviews, Inc.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2005
Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Neurological R&D, Nervous system, Neurological research, Synapses, Neurodegenerative diseases

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Molecular gradients and development of retinotopic maps

Article Abstract:

The molecular mechanisms involved in the development of a vertebrate neural map in the visual system are discussed. Axon extension, anterior-posterior (AP)-specific interstitial branching and EphBs and ephrin-Bs control dorsal-ventral (DV)- retinotopic mapping are the mechanisms for map development.

Author: O'Leary, Dennis D.M., McLaughlin, Todd
Publisher: Annual Reviews, Inc.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2005
Axons

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Mechanisms of vertebrate synaptogenesis

Article Abstract:

Synaptogenesis is a complex process involving the formation of functional synapses between neurons. Molecules derived from target neurons influence synaptic form, specificity and stability.

Author: Craig, Ann Marie, Waites, Clarissa L., Garner, Craig C.
Publisher: Annual Reviews, Inc.
Publication Name: Annual Review of Neuroscience
Subject: Science and technology
ISSN: 0147-006X
Year: 2005
Neural transmission, Synaptic transmission

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Subjects list: Research, Genetic aspects, Cytoskeleton, Vertebrates
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