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Can combination therapy overcome drug resistance?

Article Abstract:

Scientists are using multidrug combinations in an effort to overcome the resistance of the HIV virus to antiretroviral drugs. They hope that the HIV virus cannot mutate fast enough to develop immunity to all of the drugs it is exposed to. Current combination therapy research is discussed.

Author: Cohen, Jon
Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1993
HIV (Viruses), HIV, Drug resistance in microorganisms, Microbial drug resistance, Chemotherapy, Combination, Combination chemotherapy, Virus inactivation

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Results on new AIDS drugs bring cautious optimism

Article Abstract:

AIDS researchers are excited at the promise of new drugs that inhibit protease enzymes needed for HIV virus replication. The drugs were shown to reduce the amount of HIV in the blood and subsequent disease development. Clinical trials of the drugs ritonavir and indinavir are described.

Author: Cohen, Jon
Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1996
Protease inhibitors, Ritonavir (Medication), Indinavir (Medication)

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Drug companies join forces in search for AIDS therapy

Article Abstract:

Fifteen pharmaceutical companies have announced an unprecedented agreement to share research data on anti-HIV therapies in an effort to find a combination of therapies that will be effective in fighting AIDS.

Author: Cohen, Jon
Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1993
Planning, Pharmaceutical industry, Pharmaceutical research

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Subjects list: Research, Drug therapy, AIDS (Disease)
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