Chromogenic cross-link formation in green fluorescent protein
Article Abstract:
The mechanism of chromophore formation in green fluorescent protein (GFP) involves its post-translational self-modification process which yields an intrinsic fluorophore constructed from an internal main-chain cross-link. A mechanistic model of GFP involving conformational pre-organization, electrophilic and base catalysts, and production of hydrogen peroxide upon protein oxidation is developed to better understand the process.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2007
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Metal-assembled modular proteins: Toward functional protein design
Article Abstract:
The metal-assembled parallel helix-bundle proteins are used to investigate electron transfer through alpha-helical structures. The first steps toward the design of functional proteins using dynamic combinatorial assembly of alpha-helical structural elements are described.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
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