How the glucocorticoids suppress immunity

Article Abstract:

Two recent studies suggest that glucocorticoids suppress the overactive immune system by inhibiting NF-kappaB, an activator of genes needed for a strong immune defense. The knowledge may lead to new immunosuppressive drugs without the long-term side effects of glucocorticoids.

Research, Immunosuppressive agents

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Why stress is bad for your brain

Article Abstract:

Sustained stress induces overly high concentrations of glucocorticoids (GCs), which have been shown to damage the hippocampus in rodent brains. New studies link hippocampal atrophy in humans to high GC levels due to depression, Cushing's syndrome and combat stress.

Diseases, Stress (Psychology), Hippocampus (Brain)

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Mineralocorticoids, glucocorticoids, receptors and response elements

Article Abstract:

Mineralocorticoid receptors and glucocorticoid receptors are two closely associated steroid receptors. The regulatory mechanism through which the receptors achieve transcriptional specificity is described.

Hormone receptors, Mineralocorticoids

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