Optical triggers of protein folding

Article Abstract:

A technique is described that uses photoinduced electron transfer reaction to elicit folding of the reduced cytochrome c. The method, which exploits the stability difference between oxidized and reduced proteins, can be used to observe events that occur in nanoseconds and microseconds.

Research, Innovations, Biochemistry, Protein folding, Lasers, Lasers in biochemistry

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The biophysics of sickle cell hydroxyurea therapy

Article Abstract:

Research indicates that hydroxyurea effectively treats adult sickle cell anemia patients by increasing the fraction of red blood cells containing fetal hemoglobin. The biophysical mechanism involved in inhibiting polymerization in F cells is discussed.

Health aspects, Care and treatment, Sickle cell anemia, Hydroxyurea

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Nanosecond crystallographic snapshots of protein structural changes

Article Abstract:

Researchers have used time-resolved x-ray crystallography to take nanosecond long images of the changes in the structure of a protein in response to ligand dissociation and rebinding. The new technology provides atomic detail of protein function.

Usage, Proteins, X-ray crystallography, Protein structure

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