Single-molecule RNA folding

Article Abstract:

A review of the developments in the field of RNA folding that are made possible by single-molecule experiments, focusing on those using fluorescence resonance energy transfer (FRET) is presented. The results suggested that stable secondary structures are partly responsible for the rugged energy landscape of RNA, a complete mechanistic understanding of the complex folding behavior is not obtained.

Biomolecules, Catalytic RNA

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Probing single-molecule protein conformational dynamics

Article Abstract:

Protein conformational fluctuations and dynamics, often complex and associated with inhomogeneities that play a crucial role in biomolecule functions cannot be easily characterized. Single-molecule spectroscopy is powerful for identifying and characterizing spatially and temporally inhomogeneous protein conformational dynamics.

Monomolecular films, Enzymatic analysis

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Solvation dynamics and proton transfer in supramolecular assemblies

Article Abstract:

Research shows that water molecules are in a confined state in supramolecular assemblies and exhibit an ultraslow component of solvation that is slower than that in bulk water by 2-4 orders of magnitude. Data indicate that this is due to the disruption of hydrogen-bond network of water and water binding to macromolecules.

India, Influence, Electric properties, Water chemistry, Hydrogen bonding, Hydrogen bonds, Solvation, Protons, Chemical properties

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