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Structural proteomics: toward high-throughput structural biology as a tool in functional genomics

Article Abstract:

This article discusses structural proteomics research on archeaon proteins encompassing a multidisciplinary approach involving bioinformatics, molecular biology, biochemistry, and instrumentation of nuclear magnetic resonance spectroscopy and X-ray crystallography. The research focus is to develop a high-throughput facility for protein research.

Author: Edwards, Aled M., Yee, Adelinda, Pardee, Keith, Christendat, Dinesh, Savchenko, Alexei, Arrowsmith, Cheryl H.
Publisher: American Chemical Society
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2003
Canada, Protein structure, Proteomics

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Structural genomics of proteins involved in copper homeostasis

Article Abstract:

This article discusses the application of structural genomics to proteins controling metal homeostasis in general and copper homeostasis proteins in particular. The research strategy focuses on CopC protein from Pseudomonas syringae and its structural analyses.

Author: Banci, Lucia, Rosato, Antonio
Publisher: American Chemical Society
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2003
Italy, Metalloproteins, Structure

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NMR and structural genomics

Article Abstract:

Structural genomics focusing on protein structure-function determination benefits from nuclear magnetic resonace methodology. It enables to analyze protein domains in releation to its structure and role in the overall function of the protein.

Author: Staunton, David, Owen, Jo, Campbell, Jain D.
Publisher: American Chemical Society
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2003
United Kingdom, Methods, Nuclear magnetic resonance spectroscopy, Domain structure

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Subjects list: Research, Analysis, Bacterial proteins, Genomics, Structure-activity relationships (Biochemistry)
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