Comparative analysis of PAH:DNA adducts formed in lung of mice exposed to neat tar and soils contaminated with coal tar

Article Abstract:

A two-year study feeds mice with coal tar to determine the effect of the contaminants benzo(b)fluoranthene, benzo(a)pyrene, and benzo(c)fluorene. Lung tissues and tumors in the mice are evaluated for contaminants, and the results are graphed.

Pollution Control, Sanitary Services, All Other Petroleum and Coal Products Manufacturing, Animal specialties, not elsewhere classified, Laboratory Animals, All Other Animal Production, Coal Tar, Statistical Data Included, Pollution control industry, Coal industry

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Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils

Article Abstract:

Polynuclear aromatic hydrocarbons (PAH) bioavailability has been found to be greatly reduced by tar contamination from manufactured gas plants (MGP). Mice were used as subjects and results show that MGP tar resulted in 9%-75% PAH systemic bioavailability in urine and nondetectable to 76% PAH systemic bioavailability in chemical:DNA adduct formation. The results show promise in reduced PAH bioavailability when soil ingested is contaminated with MGP tar.

Environmental aspects, Soil pollution, Polycyclic aromatic compounds, Bioavailability, Tar

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Studies on the applicability of biomarkers in estimating the systemic bioavailability of polynuclear aromatic hydrocarbons from manufactured gas plant tar-contaminated soils

Article Abstract:

Polynuclear aromatic hydrocarbons (PAH) bioavailability has been found to be greatly reduced by tar contamination from manufactured gas plants (MGP). Mice were used as subjects and results show that MGP tar resulted in 9%-75% PAH systemic bioavailability in urine and nondetectable to 76% PAH systematic bioavailability in chemical: DNA adduct formation. The results show promise in reduced PAH bioavailability when soil ingested is contaminated with MGP tar. The experimental processes utilized in this study can also be used to evaluate systemic bioavailability of PAH and gastrointestinal absorption of soil contaminated with complex organic mixtures.

Article

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