The effect of sodium salicylate and aspirin on NF-kappaB

Article Abstract:

Research that attributed the anti-inflammatory nature of aspirin and sodium salicylate to the inhibition of the transcription factor NF-kappaB was extended, with the conclusion that the drugs inhibited all cellular kinases nonspecifically. A reply is included.

Aspirin, Salicylates

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A heterodimeric transcriptional repressor becomes clear

Article Abstract:

Thomas Li and colleagues have determined the crystal structure of the a1/alpha2 homeodomain heterodimer bond to DNA. These proteins play a key role in the regulation of genetic transcription.

Crystallography, DNA binding proteins

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Small RNA chaperones for ribosome biogenesis

Article Abstract:

The role played by small nuclear ribonucleoproteins (snRNPs) in the transcription of ribosomal RNA (rRNA) genes in vertebrates is examined.

Ribosomal RNA, Ribosomes

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