The raison D'etre of constitutively active protein kinases: the lesson of CK2

Article Abstract:

The catalytic activity of CK2, an active protein kinase is structurally analyzed and its functional mechanism is depicted. CK2 plays an important role in the cell by counteracting premature and unscheduled apoptosis, ensuring cell survival under stress conditions.

Dry, Condensed, and Evaporated Dairy Product Manufacturing, Dry, condensed, evaporated products, Casein

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Chemical and mechanistic approaches to the study of Protein Tyrosine Phosphatases

Article Abstract:

The role of Protein Tyrosine Phosphatases (PTPs) in signal transduction to depict its catalytic activity of substrate dephosphorylation is demonstrated. The molecular basis for PTP catalysis is reported to reveal the critical role of enzyme in cellular function

Cellular signal transduction, Phosphorylation

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Protein kinase inhibitors as a therapeutic modality

Article Abstract:

The development of tyrosine phosphorylation inhibitors as potential anticancer agents is investigated. Gleevec success in the treatment of chronic myeloid leukemia and of Iressa for lung cancer is analyzed to validate the approach.

HEALTH SERVICES, Anticancer Drugs, Cancer Therapy, Ambulatory Health Care Services, Chemotherapeutic Drugs, Anticancer Immunostimulant Preps, Antineoplastic agents, Cancer treatment, Phosphorylase, Antimitotic agents

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