Commentary on "Application of Exogenously Regulatable Promoter Systems to Transgenic Models for the Study of Aging."

Article Abstract:

Morgan et al's (1999) paper on the use of transgenic animals in gerontologic research examines the problems associated with this approach and discusses some solutions. They rightly articulate the issue in terms of gene expression at the appropriate time and place. The authors also examine the strengths and limitations of three expression systems, namely, tetracycline, RU486 and ecdysone inducible systems. The study's implications for further research are discussed.

Models, Usage, Promoters (Genetics), Genetically modified mice, Gerontology

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Cell cycle progression, aging, and cell death

Article Abstract:

The workshop on Cell Cycle Progression, Aging and Cell Death, held on Oct 6, 1993, in Bethesda, MD, helped analyze the developments in these disciplines. The workshop was sponsored by the Division of Research Grants of the National Institutes of Health. More than 150 registrants participated in discussions on molecular cytological research, genetic factors, cellular immortalization and other factors related to aging.

Reports, Observations, Forums (Discussion and debate), Cell research, Cytological research

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No evidence for a general change in contractile responsiveness of the mesenteric artery with aging

Article Abstract:

Experimental studies indicate that variations in calcium concentration or aging do not influence the contractile response of the human mesenteric artery to physiological vasoconstrictors. The reduction of extracellular ionized calcium does not inhibit contraction to U46619, a thromboxane analogue, while the contraction to noradrenaline is only slightly affected.

Mesentery, Contractility (Biology)

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