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Long-term caloric restriction improves baroreflex sensitivity in aging Fischer 344 rats

Article Abstract:

Baroreflex sensitivity, mean arterial pressure (MAP) and heart rate were compared in younger and older rats with free or calorie restricted diets to identify whether calorie restriction would reduce age-associated declines in cardiovascular function. Diet had no effect on MAP in younger rats; younger rats and ad libitum fed older rats had higher MAP that calorie restricted older rats. Heart rate was lower for calorie restricted rats regardless of age. Aging reduced reflex responsiveness, and calorie restriction increased reflex responsiveness, to nitroprusside injections.

Author: Thomas, John, Bertrand, Helen, Stacy, Cynthia, Herlihy, Jeremiah T.
Publisher: Gerontological Society of America
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1993
Aging, Low-calorie diet, Low calorie diet

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The effects of prenatal alcohol exposure on the behavior of rats during their life span

Article Abstract:

The effects of prenatal alcohol exposure on adaptive performance in rats increase with age and are most noticeable during the senile phase of life, when adaptability is at its lowest point. Rats with moderate alcohol-induced prenatal damage were compared to controls at juvenile (zero-three months), adult (three-27 months) and senile (over 27 months) stages for reflex and locomotor ability, coordination, cognitive ability and adaptation to atmospheric and pharmacological stresses. No substantial differences were found at the juvenile stage in most areas tested.

Author: Janicke, Bernhard, Coper, Helmut
Publisher: Gerontological Society of America
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1993
Research, Alcohol, Ethanol, Prenatal influences

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Effects of dietary protein restriction on nitrogen balance and cardiovascular functions in aged rats

Article Abstract:

Age-related changes in protein metabolism, such as nitrogen loss, may contribute to disease and physiological function losses. To test this hypothesis young (six-seven month) and old (24-25 month) rats were fed either a 12% or a 23% protein diet and measured for nitrogen balance and cardiovascular health. The low-protein group of older rats had positive nitrogen balance and the other group had a negative balance. Endothelium-dependent aortic relaxation was less in the low-protein rats. as were age-associated increases in platelet aggregation.

Author: Sonaka, Ichiro, Futami, Yuko, Kobayashi, Tetsuo, Umezawa, Tsutomu, Maki, Toshio
Publisher: Gerontological Society of America
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1993
Health aspects, Proteins, Nitrogen in the body, Nitrogen (Nutrient)

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Subjects list: Physiological aspects, Cardiovascular system, Circulatory system
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