Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans

Article Abstract:

Research indicates that oxidative damage is a significant factor in the life-span determination of Caenorhabditis elegans. Less oxidative damage to proteins could be associated with longer life spans, while shorter life spans could be a consequence of gene products that up-regulate free-radicals production and metabolic rate. Adult life span and larval development are both controlled by the daf-2 dauer-constitutive gene, with a mutation of daf-2 increasing life span.

---

Commentary on 'Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans.'

Article Abstract:

Studies of the genetic effects of protein oxidation by Kayo Yasuda et al indicate that there is a causal relationship between aging rate and/or life span and protein carbonyls accumulation, but there remain concerns about the supposition that protein carbonyls increase with age. Post-nuclear extracts could have been used for measurement to clarify the results.

---

Similar abstracts:

• Abstracts: Paradoxical Vasodilatation during lower body negative pressure in patients with vasodepressor carotid sinus syndrome
• Abstracts: Practical intelligence at work: relationship between aging and cognitive efficiency among managers in a bank environment
• Abstracts: Sexual relations in later life: a national study of married persons. Automatic and effortful memory processes in depressed persons
• Abstracts: Emotional intelligence in young and middle adulthood: Cross-sectional analysis of latent structure and means
• Abstracts: Maintenance requirements for dietary protein in 11- and 18-month-old male rats. Exercise reduces age-dependent decrease in platelet protein kinase C activity and translocation

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.