Increased IGF mRNA in human skeletal muscle after creatine supplementation

Article Abstract:

The responses of mRNA for insulin like growth factor-I (IGF-I) and insulin like growth factor-II (IGF-II) and the phosphorylation state of components of anabolic signaling pathways p70(super s6k) and eukaryotic initiation factor-4e binding protein-I was tested to a bout of high-intensity resistance exercise after 5 d of creatine supplementation. The increase in lean body mass often reported after creatine supplementation could be mediated by signaling pathways involving IGF and 4E-BP.

United Kingdom, Protein synthesis, Protein biosynthesis, Messenger RNA

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Effect of oral creatine supplementation on urinary methylamine, formaldehyde, and formate

Article Abstract:

The appearance of methylamine, formaldehyde, and formate, the main metabolite of formaldehyde, was investigated in the urine of healthy humans who received oral creatine supplementation, in order to examine any potential cytotoxic effects it might have. Results show that short-term, high-dose oral creatine supplementation enhances the excretion of potential cytotoxic compounds, but does not have any detrimental effects on kidney permeability.

United States, Albumin

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Calcium sensitivity of human single muscle fibers following plyometric training

Article Abstract:

The effect of plyometric training on [Ca.sup.2} sensitivity and the influence of troponin T (TnT) isoforms on [Ca.sup.2} activation properties in skinned human muscle fibers are studied. Results found a significant improvement after training for static jump, countermovement jump, 6x5-m shuttle-run test, and leg-press performances.

Analysis, Physiological aspects, Muscles, Hypertrophy, Plyometric exercises, Skeletal muscle

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