Ibutilide

Article Abstract:

The new drug ibutilide fumarate (Corvert) has been approved by the FDA for intravenous use in heart flutter and atrial fibrillation, an irregular pattern of the heart rhythm. One or two intravenous doses may restore sinus rhythm in some heart patients, based solely on the data from three manufacturer's trials. The exact drug mechanism is not known, although ibutilide prolongs action potentials in heart tissue. Ibutilide causes birth defects in rats and causes the death of rat embryos. Patients should avoid taking ibutilide with other antiarrhythmic drugs or antihistamines that do not cause drowsiness, such as terfenadine and astemizole. The evaluation of ibutilide awaits further clinical testing.

Evaluation, Anti-arrhythmia drugs, Antiarrhythmia agents

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What better time than now?

Article Abstract:

A man claims that it is his and his wife's lifelong dream of cruising that has inspired them into foregoing living on land and instead reside on board their sailboat. Although he admits that life on land is easier, he believes that he and his wife should cruise while they are still young and able to enjoy life.

Appreciation, Sailboat living

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A brother's murder

Article Abstract:

A man grieves over the physical death of his beloved younger brother who did not escape the mental death of the ghetto. The older brother had fled the self-destructive milieu and now wonders in the midst of his grief, whether or not he had tried hard enough to save his sibling.

Personal narratives, Column, History, Grief, Brothers, The New York Times Magazine (Periodical)

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