A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom
Article Abstract:
An attempt is made to show that a voltage-sensor toxin (VSTX1) from the Chilean Rose Tarantula reaches its target by partioning into the lipid membrane. Findings illustrating how nature exploits membrane partitioning of a protein toxin to achieve high apparent affinity and to deliver the toxin to its voltage sensor target are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Electron microscopic analysis of KvAP voltage-dependent K(super +) channels in an open conformation
Article Abstract:
Electron microscopy analysis is a voltage-dependent K(super +) channel from Aeropyrumpernix (KvAP)(super 3). The findings of the study supports the hypothesis that in response to changes in voltage the sensors move at the protein-lipid interface rather than in a gating pore surrounded by protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A critical ligamentous mechanism in the evolution of avian flight. Beyond the bones
- Abstracts: Structural basis of long-term potentiation in single dendritic spines
- Abstracts: Mate attractiveness and primary resource allocation in the zebra finch
- Abstracts: The mismeasure of animal contests. Honest and dishonest displays, motivational state and subsequent decisions in hermit crab shell fights
- Abstracts: Intrasexual competition and sexual selection in cooperative mammals. Play does not enhance social cohesion in a cooperative mammal