A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression
Article Abstract:
Transcript abundances across the genome during the onset of metamorphosis in 12 initially identical Drosophila melanogaster lines that independently accumulated mutations are measured to estimate the rate at which mutation produces a variation in gene expression. A strong correlation between mutational and environmental variance indicates a potential widespread canalization and gene expression does not evolve in strictly neutral models.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Expression profiling in primates reveals a rapid evolution of human transcription factors
Article Abstract:
A multi-species complementary DNA array is used to compare steady-state messenger RNA levels in liver tissues within and between humans and primates. A number of genes are found with similar expression levels among non-human primates but significantly elevated (leading to an excess of transcription factors) or reduced expression in the human lineage, which point to the action of directional selection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Constraint and turnover in sex-biased gene expression in the genus Drosophila
Article Abstract:
The comparative analysis of sex-biased expression which could explain the relationship between genome content and deployment during evolution in Drosophila species is reported. The higher DNA sequence divergence observed in male-biased expression might be attributed to high transcription rates in the male germline, greater functional pleiotropy of genes expressed in females or sexual competition.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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