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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

A new protein containing an SH2 domain that inhibits JAK kinases

Article Abstract:

Cytokines are proteins that regulate important cellular responses, such as differentiation and proliferation. They work by binding to receptors on the cell surface that are linked to members of the JAK family of cytoplasmic tyrosine kinases. A new SH2-domain-containing protein, termed JAB, has been isolated using the yeast two-hybrid system. JAB, structurally related to CIS, is a JAK-binding protein that appears to regulate functions in the JAK signalling pathway.

Author: Yoshimura, Akihiko, Taniguchi, Tadatsugu, Mitsui, Kaoru, Fujita, Takashi, Matsumoto, Akira, Endo, Takaho A., Miyazaki, Tadaaki, Masuhara, Masaaki, Yokouchi, Masahiro, Suzuki, Ritsu, Sakamato, Hiroshi, Tanimura, Shyu, Ohtsubo, Motoaki, Masawa, Hiroyuki, Leonor, Nogueira, Kanakura, Yuzuru, Komiya, Seturo
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Observations, Proteins, Protein binding, Immunological research, Immunologic research

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Angiogenic factor

Article Abstract:

Platelet-derived endothelial cell growth factor (PD-ECGF), a protein, causes angiogenesis in vivo and endothelial cell growth and chemotaxis in vitro. New research has found that the 120 amino acids for human thymidine phosphorylase are the same as PD-ECGF's sequence, indicating that the two molecules originate from the same gene. This finding may lead to further research on PD-ECGF's role in angiogenesis.

Author: Akiyama, Shin-Ichi, Yoshimura, Akihiko, Furukawa, Tatsuhiko, Sumizawa, Tomoyuki, Haraguchi, Misako, Fukui, Kiyoshi, Ishizawa, Minoru, Yamada, Yuji
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
Physiological aspects, Platelet-derived growth factor

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Lymphangiogenesis in development and human disease

Article Abstract:

Progress in the fast growing field of vascular biology with particular emphasis on the understanding and management of lymphatic, dysfunction, inflammation and tumour metastasis is summarized. Lymphangionesis research will lead to better understanding and treatment of these diseases.

Author: Alitalo, Kari, Tammela, Tuomas, Petrova, Tatiana V.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Science & research, Care and treatment, Blood circulation disorders, Vascular diseases

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Subjects list: Research, Neovascularization
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