A new target for aspirin
Article Abstract:
Yin and colleagues have reported that high aspirin concentrations inhibit the IKB kinase-Beta (IKK-Beta) enzyme and this may explain in some way the clinical efficacy of high-dose aspirin. They also show that certain other kinases such as the homologous and functionally related IKK-alpha, are not affected by aspirin. These work will lead to ne approaches to the separation of therapeutic and toxic effects of high-dose aspirin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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The importance of being selective
Article Abstract:
Hydroxylating enzymes are implicated in many biological processes by inserting O-H groups into organic compounds. Cytochrome P-450 is an oxidizing iron enzyme that introduces oxygen into the C-H bonds of molecules such as prostaglandins and steroids. A new, artificial, highly selective enzyme system has been designed that could offer catalytic routes to previously inaccessible drug intermediates.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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