A novel receptor involved in T-cell activation

Article Abstract:

An innovative glycoprotein with a relative molecular mass of 70,000 (Mr 70K) and a member of the immunoglobulin gene superfamily, designated SLAM, increases antigen-specific proliferation and cytokine production by T cells carrying the CD4 antigen. The greatest effects are seen on the production of interferon-gamma whereas no effect on the production of interleukin-4 and 5 is observed. Direct induction of the proliferation of CD4+ T-cells clones by SLAM is discussed.

Cytokines, Immunoglobulin genes

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Molecular basis for interaction of the protein kinase ZAP-70 with the T-cell receptor

Article Abstract:

An interface forming one of the two critical phosphotyrosine binding sites connected through a coiled coil of alpha-helices occurs in vivo in complex formed by association of tandem Sh2 domains of human ZAP-70 with a peptide derived from the zeta-subunit of the T-cell receptor. This structural observations for the complex formed provide an insight in to various mechanisms of molecular level activities of T-cell receptor antigen.

Methods, Molecular biology, Protein tyrosine kinase, Protein-tyrosine kinase

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A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

Article Abstract:

A study of thymocytes is discussed with reference to the effect of positive and negative selection. The results reveal that a mutation in the alphabeta T-cell receptor which mediates selection changes ERK activity and controls positive selection.

Observations, Letter to the Editor, Histocompatibility

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