P.falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1

Article Abstract:

African studies show that severe malaria is linked with the ability of erythrocytes infected with Plasmodium falciparum parasite to bind uninfected erythrocytes into rosettes. A study shows that the parasite ligand for P.falciparum clone rosetting is PfEMP1 and that complement-receptor 1 is important to the formation of rosettes. The new adhesive function for PfEMP1 is described, indicating that the CR1 polymorphisms in Africans influencing erythrocyte and PfEMP1 interaction, could protect against malaria.

Parasites, Tropical medicine

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Channelling nutrients

Article Abstract:

Researchers have described a versatile channel found in the outer membrane of infected red blood cells which helps to supply nutrients to parasite that causes malaria.

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Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P.falciparum

Article Abstract:

Research on infection by malaria parasites and antigenic variations in malaria parasites are examined in detail.

Antigen-antibody reactions

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