A role for the Ras signalling pathway in synaptic transmission and long-term memory

Article Abstract:

Genetic research shows that the neuronal-specific guanine-nucleotide-exchange factor Ras-GRF/CDC25Mm is vital to memory consolidation. Emotional conditioning experiments indicate that Ras-GRF signalling is a crucial part of the Ras/MAP kinase pathway in long-term memory formation. Electrophysiological measurements in the basolateral amygdala of Ras-GRF deficient mice demonstrate normal N-methyl-D-aspartate receptor-dependent long-term potentiation.

Neural transmission, Synaptic transmission

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Memory floxed

Article Abstract:

A mouse has been engineered in which a targeted gene has been inactivated only in specific neurons within the CA1 subregion of the hippocampus. Many of the neurons are place cells that fire impulses only when the mouse reaches a certain location. Research on the mouse reveal that gene deletion is a chronic treatment which allows neural circuitry to develop compensatory mechanisms.

Neurobiology

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