A shared but complex bridge

Article Abstract:

Gene expression must be precisely regulated and such regulation is directed by activators. Activators doe not directly interact with RNA polymerase, but use protein complexes, or mediators to relay biological signals. These mediator complexes have been identified in mammalian cells and it has been found that different activators can interact with the same mediator complex. Also many individual proteins within a mediator complex are shared between the different complexes.

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A gene complex acting downstream of dpp in Drosophila wing morphogenesis

Article Abstract:

The transcription-factor-encoding genes spalt (sal) and spalt-related (salr) act downstream of decapentaplegic (dpp) during wing development in Drosophila. The two genes are responsible for patterning of the wing in Drosophila. The expression of sal and salr genes occurs due to dpp activity in the wing's imaginal disc area. The Drosophila wing subdivides into small territories due to regulation of the transcription-factor-encoding genes which result from dpp activity.

Analysis, Observations, Drosophila, Morphogenesis

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Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

Article Abstract:

Earlier studies have shown that a secreted signalling molecule encoded by the Wnt-1 gene is essential in the development of the central nervous system. Encoding failure of the Wnt-1 gene hinders the expression of engrailed genes, located in the midbrain and anterior hindbrain. However, the expression of the engrailed genes in the developing midbrain of Wnt-1 embryos is sufficient to rescue early midbrain and anterior hindbrain development.

Physiological aspects, Central nervous system, Afferent pathways

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