Altered Hox expression and segmental identity in Mll-mutant mice

Article Abstract:

The Mll gene regulates Hox gene expression, exhibits haplo-insufficiency and is necessary for segment identity in mammals. Researchers studied the involvement of Mll in pattern development in mutant mice. Mll -/- mice died as embryos. Mll +/- mice were deformed and growth retarded. They also had segment identity abnormalities aw well as caudal shifts. Mll-mutant mice have many features in common with trx mutants.

Analysis, Genetic regulation, Developmental genetics, Mutation (Biology), Mutation, Neural transmission, Neural transmission regulation

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Bax suppresses tumorigenesis and stimulates apoptosis in vivo

Article Abstract:

The role of the death-promoting gene Bax in a transgenic mouse brain tumor was examined using a model in which protein p53-mediated apoptosis attenuates tumor growth. It was found out that inactivation of p53 accelerates tumor growth due to a reduction in apoptosis. The results suggest that Bax, which functions as a tumor suppressor, may have an important role in the p53-mediated apoptotic response.

Genetic aspects, Cell death, Tumor suppressor genes, Carcinogenesis

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1

Article Abstract:

Mice conditional for Mcl- 1 display a profound reduction in B and T lymphocytes when MCL-1 is removed. Deletion of Mcl- 1 during early lymphocyte differentiation increased apoptosis and arrested the development at pro-B-cell and double- negative T- cell stages.

Science & research, Cells (Biology), Cells, Lymphocytes

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