Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1

Article Abstract:

Immunohistochemistry and in situ hybridization were performed to investigate the role of Hoxb-1 gene in the organization of motor neurons in mice. Hoxb-1 has been known to be expressed in rhombomere 4 (r4) and the results of the experiment confirmed that its absence causes changes in the identity of r4. The results further showed that Hoxb-1 plays the role of maintaining rhombomere identity by controlling the migratory properties of motor neurons in the hindbrain.

Usage, In situ hybridization, Motor neurons, Molecular biology, Mice as laboratory animals, House mouse, Molecular genetics, Immunohistochemistry

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High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC

Article Abstract:

A study of mice with mutated cells found that those that were homozygous for the xerodema pigmentosa Group C mutant allele had a higher incidence of tumor growth than a control population or mice heterozygous for the mutant allele. The mice were mutated using embryonic stem cell technology.

Physiological aspects, Ultraviolet radiation, Carcinogenesis, Xeroderma pigmentosum

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Targeting of sheep

Article Abstract:

Issues are presented concerning the use of transgenic technology in the breeding of sheep. The benefits and the limitations of this genetics procedure are discussed.

Genetic aspects, Genetically modified animals, Sheep breeding

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