Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene

Article Abstract:

High levels of truncated utrophin transgene expression in the skeletal muscle and diaphragm reduces the dystrophic muscle pathology in dystrophin-deficient mdx mice. Utrophin is a protein related to dystrophin. It's upregulation can compensate for the deficiency of dystrophin in all the pertinent muscles of a mouse suffering from the duchenne muscular dystrophy. Increase in the utrophin muscle expression extends life by preserving cardiac and respiratory muscles.

Usage, Physiological aspects, Proteins, Phenotype, Phenotypes, Mice as laboratory animals, House mouse, Dystrophin

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Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice

Article Abstract:

Adenoviruses were used to mediate the successful transfer of human minidystrophin genes to mdx mice's skeletal muscle as a treatment for X-linked Duchenne progressive muscular dystrophy. The transfer was able to encourage the production of dystrophin whose absence causes the disease. Adenoviruses can infect post-mitotic cells, are stable and can infect many tissues so they are very useful in the introduction of foreign genetic material.

Health aspects, Methods, Gene therapy, Adenoviruses, Human, Human adenoviruses

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Clone mammals...clone man?

Article Abstract:

The research that revealed the production of viable sheep from an adult cell has implied that it is possible to visualize cloning of mammals by asexual means therefore human cloning could become feasible. However, creating human clones would contradict to an ethical principle of human dignity which constitutes uniqueness and unpredictability of a person. This moral barrier would protect humankind from the perspectives mentioned.

Cloning

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