Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

Article Abstract:

The endocannabinoid anandamide and its metabolite arachidonic acid activating TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids are presented. An analysis on this acid identified the endocannabinoids and arachidonic acid as endogenous chemchemical activators of TRP4.

Transition state (Chemistry), Metabolites

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Enhanced gravi- and phototropism in plant mdr mutants mislocalizing the auxin efflux protein PIN1

Article Abstract:

Research has been conducted on plant mdr mutants. The authors demonstrate that these mutants have faster gravitropism and enhanced phototropism, and that these phenotypes are the results of the disruption of PIN1 protein accumulation along the basal end of hypocotyl cells which are associated with basipetal auxin flow.

Analysis, Plants, Plants (Organisms), Proteins, Phenotype, Phenotypes, Auxin, Auxins, Genetic research, Phototropism

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Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells

Article Abstract:

Research has been copnducted on cystic fibrosis transmembrane conductance regulator. The authors describe the study of phosphorylation- and ATP-independent activation of this regulator by cytoplasmic glutamate.

Causes of, Glutamate, Phosphorylation, Adenosine triphosphate, ATP, Cystic fibrosis, Epithelium, Chemical properties

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