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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I-kappa-B kinase

Article Abstract:

It has been possible to demonstrate an unusual mechanism of anti-inflammatory activity based on the direct inhibition and modification of the IKK-beta subunit of I-kappa-B kinase. IKK-beta activates NF-kappa-B by pro-inflammatory stimuli, and this research therefore demonstrates how cyclopentenone prostaglandins act and can be used to boost the utility of COX2 inhibitors. This research indicates that cyclopentenone prostaglandin and possibly stronger derivatives could play a valuable role in the treatment of inflammatory and viral diseases, along with some cancers.

Author: Rossi, Antonio, Kapahi, Pankaj, Natoli, Gioacchino, Takahashi, Takayuki, Chen, Yi, Karin, Michael, Santoro, M. Gabriella
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Inflammation, Prostaglandins, Inflammation mediators

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NAK is an IkB kinase-activating kinase

Article Abstract:

An IKB kinase (IKK)-related kinase, NAK that can activate IKK via direct phosphorylation, is described.

Author: Chen, Yi, Karin, Michael, Tojima, Yuichiro, Fujimoto, Atsushi, Delhase, Mireille, Hatakayama, Shigetsugu, Nakayama, Kei-ichi, Keneko, Yoko, Nimura, Yuji, Motoyama, Noboru, Ikeda, Kyoji, Nakanishi, Makoto
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Observations, Phosphorylation

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IKK-varGamma is an essential regulatory subunit of the IvarKappaB kinase complex

Article Abstract:

The transcription factor NF-varKappaB is activated by pro-inflammatory cytokines by the stimulation of a protein kinase, phosphorylating IvarKappaB. This leads to the translocation of freed NF-varKappaB dimers and activation of transcription of target genes, many of which code for immunoregulatory proteins. The IKK complex has been purified to homogeneity from human cell lines and it was found to comprise similar amounts of IKK-alpha, IKK-beta and two other polypeptides.

Author: Natoli, Gioacchino, Karin, Michael, Zandi, Ebrahim, Rothwarf, David M
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
Protein kinases, Cytokines

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