Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

Article Abstract:

Research is presented concerning the influence of Cyclin E-Cdk2 levels of activity on the exit from the cell cycle during mammalian embryogenesis and the development of Drosophila. The role of protein degradation is discussed.

Physiological aspects, Proteins, Drosophila, Embryology, Animal embryology, Letter to the Editor

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A recurrent mutation in PALB2 in Finnish cancer families

Article Abstract:

Researchers have shown, by screening for PALB2 mutations in Finland that a frameshift mutation, is present at elevated frequency in familial breast cancer cases compared with ancestry-matched population controls. The results have indicated that PALB2 is a breast cancer susceptibility gene that might also contribute to familial prostate cancer development.

Breast cancer, Genetic susceptibility, BRCA mutations

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Isolation of rare circulating tumour cells in cancer patients by microchip technology

Article Abstract:

The construction of a novel microfluidic system (the' CTC-chip') for effective and selective disintegration of feasible circulating tumor cells (CTCs) from peripheral whole blood samples, intervened by the interaction of target CTCs with antibody (EpCAM)-coated microposts under accurately controlled laminar flow conditions is described. The CTC-chip is efficient in precise identification and measurement of CTCs in cancer patients.

Semiconductors and related devices, Semiconductor and Related Device Manufacturing, Integrated & Hybrid Circuits, Integrated Circuits, Semiconductor chips, Technology application, Cancer cells, Metastasis, Cancer metastasis, Tumors, Tumor blood vessels, Standard IC, Tumour blood vessels

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