Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye
Article Abstract:
Planar polarity is observed in epidermal structures throughout the animal kingdom. It is reflected in the Drosophila eye in the mirror-symmetric arrangement of ommatidia over the dorsoventral midline or equator. Notch and Delta (D1) have been identified as dominant enhancers of the phenotypes produced by fz and dishevelled (dsh) overexpression. D1-mediated activation of Notch is need to establish ommatidial polarity, and while fz signalling is needed to specify R3 photoreceptors, Notch signalling induces the fate of R4.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing
Article Abstract:
It is unknown how the coordination of the regulation of cell proliferation and patterning of cell fates is achieved. In the developing Drosophila wing, the secreted morphogen Wingless (Wg) is required for both cell proliferation and patterning. The way in in which Wg coordinates the cell cycle with patterning has been investigated by looking at the regulation of such growth arrest. Wg is shown to work in conjunction with Notch, to induce arrest in the G1 and G2 stages of the cell cycle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Scabrous complexes with Notch to mediate boundary formation
Article Abstract:
Research is presented concerning the mechanisms which sharpen and establish pattern in the developing nervous system in Drosophila retinal proneural clusters. The influence of the signalling transmembrane receptor Notch is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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