Atomic structure of the ectodomain from HIV-1 gp41
Article Abstract:
It is possible to use X-ray crystallography to investigate the structure of the protease-resistant part of a gp41 ectodomain solubilized with a trimeric GCN4 coiled coil replacing the amino-terminal fusion peptide. A number of features of the coiled coil indicate a common mechanism with the transmembrane subunit of Moloney murine leukaemia virus for initiating fusion. Key features include a carboxy-terminal alpha-helix packing in the reverse direction against the outside of the coiled coil. This means that the amino and carboxy termini are situated near each other at one end of the long rod.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Amantadine blocks the channel
Article Abstract:
The anti-influenza drug amantadine prevents the influenza virus membrane proteins (M2) from functioning as an ion channel which in turn prevents the virus from infecting cells. However, L.H. Pinto and colleagues also found that amantadine did not inhibit mutant forms of M2 from functioning as an ion channel. These findings, achieved by injecting M2 messenger RNA into oocytes and then measuring the total membrane currents, may lead to new antiviral channel blockers and perhaps to a prophylactic for influenza.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Influenza drug could abort a pandemic
Article Abstract:
The neuraminidase-inhibitors zanamivir/Relenza and oseltamivir/Tamiflu are the two safe antiviral drugs that are effective against all flu viruses, including H5N1. These drugs should be taken after the infection is revealed by a rapid flu test and thus can help in curtailing the infection by influenza virus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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