Biology's new Rosetta stone

Article Abstract:

The completion of the sequencing of the entire yeast (Saccharomyces cerevisiae) genome was likened to finding a new Rosetta stone. Roughly 6,200 proteins from an estimated 4,000 homologous protein families are encoded on the 16 yeast chromosomes, undoubtedly representing most eukaryotic protein families. The analysis of these data will be instrumental for the understanding of the genomes of other eukaryotes. Research still needs to be done on multiple-domain proteins and regulatory and metabolic pointers to be able to eventually provide a fully integrated yeast genome database.

Genetic aspects, Eukaryotic cells, Cells (Biology), Eukaryotes, Saccharomyces

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Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

Article Abstract:

There is a specific functional binding between the yeast activator Gcn4 or the VP16 activation domain with the Spt-Ada-Gcn5-acetyltransferase and NuA4 histone acetyltransferase (HAT) complexes. There is no interaction between the yeast HAT complexes Ada and NuA3, thus showing that the interaction of activator and HAT must be specific. It has been possible to demonstrate the targeting of native HAT complexes by a transcription-activation domain to nucleosomes to activate transcription.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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