Thalidomide's chirality
Article Abstract:
A clear enantio-selectivity towards the S-thalidomide was found in all analogues tested to determine whether its inhibition of the release of tumour necrosis factor (TNF)-alpha from activated mononuclear human blood cells is enantio-selective. The S-form of thalidomide allows a slight yet statistically substantial increase in the degree of TNF-alpha inhibition, as against the R-form. Thalidomide derivatives in sedation and teratogenicity also showed enantioselectivity towards the S-form, indicating that stereochemistry cannot separate desired and adverse effects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Absolute configuration of chirally deuterated neopentane
Article Abstract:
A study was conducted to show that instrumental advances in Raman optical activity, combined with quantum chemical computations could make it possible to determine the absolute configuration of (R)-[[sup.2.H.sub.1], [sup.2.H.sub.2], [2.sup.H.sub.3]]-neopentane. The saturated hydrocarbons are found to represent the archetype of all molecules that are chiral as a result of a dissymmetric mass distribution.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Influence of environmental changes on degradation of chiral pollutants in soils
Article Abstract:
Field and laboratory experiments demonstrated the influence of environmental changes on the degradation of chiral pollutants in soils. Most pasture samples in Brazilian soils preferentially transformed the non-herbicidal enantiomer of dichlorprop, and most forest samples transformed the herbicidal enantiomer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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