Blood substitutes and infection
Article Abstract:
Genetically-engineered hemoglobin cannot be considered a safe blood substitute until it is freed of extracellular hemoglobin's tendency to produce bacterial infections. Genetically-engineered or human recombinant hemoglobin has been suggested as an means of maintaining the oxygen-carrying capacity of red blood cells while blocking the transmission of viral pathogens. The hemoglobin molecule's affinity for oxygen makes it suitable for this role. However, further research is needed on how to engineer the hemoglobin molecule so that it will not foster the growth of bacteria.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase
Article Abstract:
It has been established that enzymatic quenching of acyl-homoserine lactone quorum-sensing signals is a viable technique for prevention of bacterial infection. This work indicates a promising potential for the use of quorum-sensing signals as molecular targets for disease control.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Quieting the raucous crowd
Article Abstract:
New research has identified a promising method for controlling Erwinia infections. The researchers used Erwinia's quorum-sensing signals to develop a new technique for controlling quorum-regulated processes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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