Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

Article Abstract:

Research illustrates the regulation of the proliferative activity of normal stem and progenitor cells mediated by the Polycomb group gene Bmi-1. Results show that both leukaemic stem and progenitor cells without Bmi-1 stop proliferation and show signs of differentiation and apoptosis. Complementation analysis demonstrate that Bmi-1 rescues the proliferative defects.

Canada, Science & research, Research, Cell differentiation, Stem cells, Leukemia, Cell proliferation, Apoptosis

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Archipelago of destruction

Article Abstract:

Issues are presented concerning the physiological processes which control the cell-division cycle through the activity of enzymes and enzyme regulators. The mutation of a regulator in some cancer cells is discussed.

Enzymes, Enzyme regulation

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Burning the spindle at both ends

Article Abstract:

Information about transmission of genome during cell division is given. The requirements of the experiment conducted are also highlighted.

Genomes

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