CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen

Article Abstract:

CD1b, a protein product of the CD1 locus, restricts the proliferation and cytotoxicity responses of human CD4(super -)8(super -) T lymphocytes to the Mycobacterium tuberculosis antigen. The responses depend on CD1b being expressed by the antigen-presenting cell, but are independent of molecules encoded by the major histocompatibility complex. The molecules in the CD1 family seem to function as antigen-presenters and are involved in cell-mediated immunity to microbial pathogens.

Genetic aspects, T cell antigen receptors, T cells, Antigen presenting cells, Lymphocytes

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Cloning and characterization of a new intercellular adhesion molecule ICAM-R

Article Abstract:

The molecular clone of a newly identified human intercellular adhesion molecule (ICAM), designated ICAM-R, has been obtained. ICAM-R is expressed by a complementary DNA molecule whose 1,781 base pairs generate a protein with five extracellular immunoglobulin-related type domains. Like the previously identified ICAMs, ICAM-R participates in regulating the immune response by influencing the leukocyte function-associated antigen.

Cell adhesion molecules, Leukocytes, White blood cells

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Extreme Th1 bias of invariant V-alpha-24J-alpha-Q T cells in type 1 diabetes

Article Abstract:

Research into insulin-dependent diabetes mellitus (IDDM) indicates a model in which Th1-cell-mediated tissue damage is initially controlled by V-alpha-24J-alpha-Q+ T cells producing both cytokines. IDDM is linked with the loss of the capacity of these cells to secrete interleukin (IL)-4. V-alpha-24J-alpha-Q+ T cells may be functionally linked with the resistance or progression of IDDM in humans.

Causes of, Type 1 diabetes

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