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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

CD1c-mediated T-cell recognition in isoprenoid glycolipids in Mycobacterium tuberculosis infection

Article Abstract:

It has been possible to define a new class of widely distributed lipid antigens presented by the CD1 system during infection in vivo. T-cell activation by recognition of dolichols provides a mechanism for immune recognition of changes in the level or structure or isoprenoid glycolipids.

Author: Moody, D. Branch, Ulrichs, Timo, Muhlecker, Walter, Young, David C., Gurcha, Sudagar S., Grant, Ethan, Rosat, Jean-Pierre, Brenner, Michael B., Costello, Catherine E., Besra, Gurdyal S., Porcelli, Steven A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Mycobacterium tuberculosis, Cell differentiation

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Apolipoprotein-mediated pathways of lipid antigen presentation

Article Abstract:

The pathways mediating markedly efficient exogenous lipid antigen delivery by apolipoproteins to achieve T-cell activation is defined. Apolipoprotein E binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells.

Author: Moody, D. Branch, Brenner, Michael B., Besra, Gurdyal S., Sacks, Frank M., Kent, Sally C., Elzen, Peter van den, Illarionov, Petr A., Garg, Salil, Leon, Luis, Tan-Yun Cheng, Brigl, Manfred, Dascher, Chris C., Leadbetter, Elizabeth A., Gumperz, Jenny E.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Apolipoproteins, Antigens

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CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor

Article Abstract:

The structure of a human natural killer T cell receptor (NKT TCR) in complex with CD1d bound to the potent NKT-cell agonist [alpha]-galactosylceramide, the archetypal CD1d-restricted glycolipid is described.

Author: Besra, Gurdyal S., Godfrey, Dale I., Wilce, Matthew C.J., Rossjohn, Jamie, Borg, Natalie A., Kwok S. Wun, Kjer-Nielsen, Lars, Pellicci, Daniel G., Koh, Ruide, Bharadwaj, Mandvi, McCluskey, James
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Science & research, Antigen receptors, T cell, T cell antigen receptors, Structure, Cell anatomy

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Subjects list: Research, Glycolipids, T cells
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