CD69 acts downstream of interferon-alpha/beta to inhibit S1P(sub 1) and lymphocyte egress from lymphoid organs

Article Abstract:

The treatment with the interferon IFN-alpha/beta inducer polyinosine polycytidylic acid (poly(I:C)) inhibits egress by a mechanism that is partly lymphocyte-intrinsic. The transmembrane C-type lectin CD69 is rapidly induced and CD69(super -/-) cells are poorly retained in lymphoid tissues after treatment with poly(I:C) or infection with lymphocytic choriomeningitis virus, indicating that CD69 forms a complex with and negatively regulates SIP(sub 1)and functions downstream of IFN-alpha/beta.

Science & research, Cell receptors, Lymphatics, Lymphatic system

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Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

Article Abstract:

The interaction of the Gab1 protein substrate and the c-met receptor encoded tyrosine kinase leads to epithelial morphogenesis. The proline-rich domain of the protein binds it to the tyrosine-phosphorylated bidentate docking site in c-met. This induces the c-met specific activities such as branching morphogenesis in the epithelial cells. The Gab1 expression stimulates the c-met signals, whereas, the overexpression of Gab1 including only the c-met binding domain suppresses the c-met signals.

Observations, Epithelial cells, Protein tyrosine kinase, Protein-tyrosine kinase, Morphogenesis

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Article Abstract:

The process of Lymphocyte is discussed. The various after effects are also illustrated.

Cell migration, Lymphocytes, Sphingosine

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