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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

Article Abstract:

Card9 is identified as a key transducer of Dectin-1 signalling that operates as a key adaptor for non-Toll-like receptors (non-TLRs) pattern recognition receptors (PRRs) signal transduction, which is required to link Dectin-1/Syk activation to Bcl-10-Malt1-dependent NF-kB activation for innate anti-fungal immunity. The results have defined an innate immunity pathway and have showed that evolutionarily distinct immunoreceptor tyrosine-based activation motif (IATM) receptors in innate and adaptive immune cells use diverse adaptor proteins to engage selectively the conserved Bcl10-Malt1 module.

Author: Schafer, Martin, Ruland, Jurgen, Forster, Irmgard, Peschel, Christian, Gross, Olaf, Gewies, Andreas, Finger, Katrin, Sparwasser, Tim
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United Kingdom, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Antifungal Preparations, Health aspects, Immunosuppression, Antifungal agents

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Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

Article Abstract:

Impedes Mitogenic signal Propagation (IMP) functions as a threshold modulator which controls sensitivity of the cascade to stimulus. It provides a mechanism to allow adaptive behavior of the cascade in chronic or complex signalling environments.

Author: White, Michael A., Matheny, Sharon A., Chen, Chiyuan, Kortum, Robert L., Razidlo, Gina L., Lewis, Robert E.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
United States, Protein kinases, Mitogens

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Subjects list: Research, Cellular signal transduction
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