Cbl-b regulates the CD28 dependence of T-cell activation

Article Abstract:

Deficiency of the adaptor molecule Cbl-b leads to impaired CD28 surveillance on T-cell activation. This is, at least partially, responsible for the raised susceptibility of mutant mice to autoimmune diseases. It was established that Cbl-b does not have a significant impact on the main T-cell antigen receptor (TCR) signalling pathways, while loss of Cbl-b correlates with Vav activation. It is possible that Cbl-b affects the CD28 dependence of T-cell activation by selectively suppressing TCR-mediated Vav activation.

Antigen receptors, T cell, T cell antigen receptors

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

Article Abstract:

The simultaneous blockade of the CD28 and CD40 pathways prevents rejection of skin and cardiac allografts and encourages their long-term acceptance by suppressing T-cell clonal expansion in vitro and in vivo. The blockade suppresses the immune responses that are controled by the T-cells. Inhibition of only one pathway is insufficient to prevent graft rejection. This shows that the paths are related to each other but function independently.

Analysis, Graft rejection, T cells, Homografts

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Decoy receptors thwart B cells

Article Abstract:

Two receptors for the protein, BAFF, implicated in lupus erythematosus, have been identified.

Lupus erythematosus

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