Cdc25 cell-cycle phosphatase as a target of c-myc

Article Abstract:

The cdc25A cell-cycle phosphatase gene is an important transcriptional target for the proto-oncogene c-myc, and its expression is necessary for c-myc protein (Myc) -dependent apoptosis in certain cells. Myc-activation increases cdc25A messenger RNA and protein levels. Myc directly affects cdc25A transcription and its oncogenic properties are necessary for cdc25A activation. The three Myc/Max binding sites in the cdc25A gene regulate the Myc-dependent transcription. The cdc25A and cdc25B genes have a cooperative action on Myc-dependent cell-cycle activation and apoptosis.

Physiological aspects, Phosphatases, Proto-oncogenes

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A fate worse than death

Article Abstract:

The genes regulating apoptosis are transcriptionally controlled by a family of transcription factors that are evolutionarily conserved. These factors have positive and negative effects on cell survival. Ces-2 and hepatic leukaemia factor are members of bZIP transcription factors subfamily. Inactivation of CES-2 may cause abnormal neural development and expression of the latter may result in leukaemia. Three mammalian transcription activators are hepatic leukaemia factor, thyrotroph embryonic factor/vitellogenin gene binding protein and albumin D-element binding protein.

Leukemia

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Bcl-x(sub L) forms an ion channel in synthetic lipid membranes

Article Abstract:

Bcl-x(sub L), an apoptosis of inhibitor, possesses the ability to form ion channels in biological membranes, like the pore-forming domains of bacterial toxins. Bcl-x(sub L) can insert into either synthetic lipid vesicles or planar lipid bilayers and form an ion-conducting channel. The ion-conducting channels exhibit multiple conductance states with identical ion selectivity. They are also pH-sensitive and become cation-selective at physiological pH. Their regulation of membrane permeability may help them modulate cell survival.

Research, Analysis, Proteins, Ion channels, Lipid membranes

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