Cell-cycle control and its watchman
Article Abstract:
The tumor-suppressor p53 protein acts through other proteins such as p21 to regulate the cell cycle. The p53 protein blocks cell division if there is DNA damage or a defect in the sequence of cell division. Tumor cells lacking p21 undergo many S phases without further progress into mitosis on exposure to DNA-damaging drugs. This indicates that p53 ensures that a S phase does not start without an intervening M phase. It is also likely that p53 prevents entry into the M phase if the DNA is damaged. Therapies that ensure proper functioning of p53 will be useful for tumor control.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A checkpoint on the road to cancer
Article Abstract:
Research has established that cancer cells contain mutations which impact the cell division process, causing a change in cell chromosome number and an increase in mutant genes. Aneuploidy occurs when a 'checkpoint' process fails during cell division. The way in which anauploidy leads to tumour progression is debated. Some researchers believe that mutability is a feature of tumour cell genomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Creation of human tumour cells with defined genetic elements
Article Abstract:
The telomere biology of rodent and human cells is different in that murine somatic cells express telomerase activity and have longer telomeres than human cells, which lack telomerase activity. Ectopic expression of the telomerase catalytic subunit (hTERT) together with two oncogenes, leads to direct tumorigenic conversion of normal human epithelial and fibroblast cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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