Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Article Abstract:

A study reveals that delta-like4 (Dll4)-Notch1 signalling has regulated the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina. The results have indicated that Dll4-Notch1 signalling between endothelial cells within the angiogenic sprout has restricted the tip-cell formation in response to vascular endothelial growth factor and they can be used as pharmacological regulators of angiogenesis.

Sweden, Cell hybridization, Endothelial growth factors

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Article Abstract:

Bone marrow-derived haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) appear to home in on tumour-specific pre-metastatic sites and VEGFR1(super plus) form cellular clusters before the arrival of tumour cells. These cells express VLA-4 and tumour -specific growth factors upregulate fibronectin-a VLA-4 ligand in resident fibroblast, providing a permissive niche for incoming tumour cells.

United States, Metastasis, Cancer metastasis, Bone marrow cells, Transforming growth factors, Structure

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Inhibition of Dll4 signalling inhibits tumor growth by deregulating angiogenesis

Article Abstract:

A study shows that the Dll4-mediated Notch signaling has a unique role in regulating endothelial cell proliferation and differentiation. It is also revealed the Notch signaling is crucial during active vascularization, but less important for normal vessel maintenance.

Cell differentiation, Cell proliferation

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