Cell-permeant caged INsP(sub3) ester shows that Ca(super2+) spike frequency can optimize gene expression

Article Abstract:

Calcium is released from intracellular stores by inositol 1,4,5-trisphosphate (InsP(sub3)), and complex waves and oscillations in cytosolic free calcium levels are triggered. A membrane-permeant caged InsP(sub3) derivative from myo-inositol has been synthesized to determine which long term responses are controlled by InsP(sub3) oscillations. An InsP(sub3) analogue was uncaged and was found to be almost as potent as real InsP(sub3). Thus gene expression for a given amount of InsP(sub3) is maximized by oscillations in cytosolic free calcium levels at about physiological rates.

Research, Observations, Cells (Biology), Gene expression, Cells, Inositol

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AZT critics 'swayed South African president.'

Article Abstract:

South African President Thabo Mbeki's comments that the anti-retroviral drug AZT could be too toxic for use in treating patients with HIV may have been inspired by lawyer Anthony Brink, whose views seem to be similar to those of US molecular biologist Peter Duesberg. South African Minister of Health Manto Tshabalala-Msimang has stated that the AZT will not be made routinely available at state hospitals until a full report is published by the Medicines Control Council, South Africa's statutory body for drug control. However, AZT will not be withdrawn at this stage.

South Africa, Dosage and administration, Medical policy, Health policy, Zidovudine

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Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy

Article Abstract:

Many current treatments for human immunodeficiency virus (HIV)-1 infection such as zidovudine inhibit the viruses' reverse transcriptase. Research shows that attacking the virus with multiple inhibitors may adversely affect its viral replication as separate mutations are required to combat each inhibitor. This therapy is called convergent combination therapy and may successfully limit or prevent HIV infection by preventing viral replication. This technique may help overcome the tendency of HIV-1 to become resistant to antiviral drugs.

Health aspects, Prevention, HIV (Viruses), HIV, Drug resistance in microorganisms, Microbial drug resistance, Reverse transcriptase, Enzyme inhibitors

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