Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

Article Abstract:

Studies are conducted to show that a specific proline (Pro 8*), located at the apex of the loop between the second and third transmembrane helices of the 5-Hydroxytryptamine type 3 (5-HT3) receptors, links binding to gating through a cis-trans isomerization of the protein backbone. Results confirm the crucial role of Pro-8* in the 5-HT3 receptor and it is suggested that a molecular rearrangement at Pro 8* is the structural mechanism that opens the receptor pore.

Isomerization, Neurotransmitters

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Chloride/proton antiporter activity of mammalian CLC proteins CIC-4 and CIC-5

Article Abstract:

An analysis reported that mammalian proteins CLC-4 and CLC-5 carry a substantial amount of protons across the plasma membrane when activated by positive voltages. Both proteins are able to extrude protons against their electrochemical gradient demonstrating secondary active transport.

Analysis, Acid deposition, Hydrogen-ion concentration, pH measurement

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Molecular code for transmembrane-helix recognition by the Sec61 translocon

Article Abstract:

The article explains a newly devised molecular code for the recognition of the transmembrane-helix by the Sec61 translocon. The quantitative analysis of position dependent amino acids to membrane efficiency is performed.

Measurement, Gibbs' free energy, Membrane lipids

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