Clarifying the mechanics of DNA strand exchange in meiotic recombination

Article Abstract:

The genetic studies have revealed new information about the role of meiosis-specific DNA strand exchange protein disrupted meiotic cDNA1 (Dmc1) and accessory proteins that modulate Dmc1 function in meiotic recombination. Such genetic and biochemical breakthroughs promise to answer long-standing questions about the mechanism of meiotic recombination.

Genetic aspects, Cell division, DNA binding proteins

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DNA twists and flips

Article Abstract:

DNA can shape itself into many forms and the crystal structure of the junction between two of its forms can be used to describe how DNA might accomplish some of the activities of life. The structures of the B-Z junction of the DNA and the features of Z-DNA are described.

Crystals, Crystal structure

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Catalyst of a catalyst

Article Abstract:

The identification of the human BRCA2 gene was a landmark discovery in the field of breast cancer. Mutations in this gene result in a dramatically increased predisposition to breast cancer, as well as to other tumour types.

Breast cancer, Protein research

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