Structural basis for broad DNA-specificity in integron recombination
Article Abstract:
The crystal structure of an integron integrase bound to a secondary target site (attC) substrate is reported. The structure shows that DNA target site recognition and high-order synaptic assembly are not dependent on canonical DNA but on the position of two flipped-out bases that interact in cis and in trans with the integrase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Transposition of hAT elements links transposable elements and V(D)J recombination
Article Abstract:
Transposons are DNA sequences that encode functions that promote their movement to new locations in the genome. The mechanism of DNA breakage and joining that underlies hAT element transposition are determined by using purified Hermes transposase and amino acids critical for the catalytic steps of recombination are identified.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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